NG+ technically is supported and tested.Suggested level for comfort walkthrough: 50.Also it's recommended to complete/watch ' Blood Simple' Orianna's quest (Unseen Elder path) to avoid spoilers and misunderstandings.
This quest continues the events of Blood & Wine, so it's required that you've completed main story of this DLC. A Night to Remember is a completely new adventure featuring characters new and old! You can enjoy new writing, cutscenes, voice acting, assets, a special reward, and some difficult decisions.